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Objective: To improve the clinical translation of animal‐based NSPC therapies to humans, we assessed the effect of inflammatory and regenerative factors on primary spinal cord NSPCs in a small (rat) and large (pig) animal model in comparison to NSPCs from humans. University of Ottawa, Neurosurgery, Ottawa, Canadaīackground: While the use of neural stem/progenitor cells (NSPCs) has been reported as a promising therapeutic approach for spinal cord injury repair, the direct comparison of adult primary animal spinal cord NSPCs have not been directly compared to human NSPCs under the same culture conditions to characterize intrinsic differences between human and animal NSPC response to inflammatory and regenerative factors. 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